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Acefylline

A potential Peptidylarginine deiminase (PAD) activator
Catalog #: B3119
SKU-Size Size Price Qty
B3119-10G 10 g
$60.00
B3119-25G 25 g
$125.00
More Sizes Get Quote

Product Details

Alternate Name Theophylline-7-acetic acid; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid; 7-(Carboxymethyl)theophylline; (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid; 2-(1,3-Dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetic acid; 1,3-Dimethylxanthine-7-acetic acid; 2-(1,3-dimethyl-2,6-dioxo-1,3,7-trihydropurin-7-yl)acetic acid
Appearance White to off-white powder
CAS # 652-37-9
Molecular Formula C₉H₁₀N₄O₄
Molecular Weight 238.2
Purity ≥ 98%
Solubility ~33 mg/ml in DMSO (may need ultrasonication)
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)O
InChi InChI=1S/C9H10N4O4/c1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h4H,3H2,1-2H3,(H,14,15)
InChi Key HCYFGRCYSCXKNQ-UHFFFAOYSA-N
PubChem CID 69550
MDL Number MFCD00022832
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acefylline is a xanthine derivative which acts as potential Peptidylarginine deiminase (PAD) activator. It increases the in vitro deimination of filaggrin by PAD1 and PAD3 at a concentration of 200 μM. It enhances deimination in the stratum corneum which is essential for epidermal photoprotection and moisturizing of the stratum corneum. Acefylline is also a bronchodilator, which inhibits rat lung cAMP phosphodiesterase isoenzymes.


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