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Acebilustat

A potent and selective leukotriene A4 hydrolase inhibitor
Catalog #: B3206
SKU-Size Size Price Qty
B3206-5 5 mg
$165.00
B3206-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name CTX4430; 4-(((1S,4S)-5-(4-(4-(oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid; EP501; ZK322
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 943764-99-6
Molecular Formula C₂₉H₂₇N₃O₄
Molecular Weight 481.55
Purity ≥98%
Solubility >15 mg/ml DMSO
SMILES O=C(O)C1=CC=C(CN2[[email protected]](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[[email protected]]3([H])C2)C=C1
InChi InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1
InChi Key GERJIEKMNDGSCS-DQEYMECFSA-N
PubChem CID 68488178
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H) catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.


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