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ACE1 Inhibitor Screening Kit (Colorimetric)

for high-throughput screening of ACE1 inhibitors
Catalog #: K719
$745.00

Product Details

Cat # +Size K719-100
Size 100 assays
Kit Summary BioVision’s ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in OD at 345 nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the OD at 345 nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.
Detection Method Absorbance, OD 345 nm
Species Reactivity Mammalian
Applications Screening/characterizing ACE1 inhibitors
Features & Benefits • Reliable test for high-throughput screening of ACE1 inhibitors
• Rapid
• Simple
Kit Components • ACE1 Enzyme
• 96-Well UV Transparent Plate
• ACE1 Assay Buffer
• ACE1 Inhibitor Control
• ACE1 Substrate
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Angiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. ACE is a key part of the renin angiotensin system that regulates blood pressure. ACE inhibitor inhibits ACE1 enzymatic activity and decreases the production of angiotensin II. As a result, blood vessels are dilated thereby increasing the amount of blood pumped by the heart and lowering the blood pressure. ACE inhibitors are used for treating hypertension, heart failure, stroke etc. Recent research is also focused on the discovery of natural products as ACE1 Inhibitors. BioVision’s ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in OD at 345 nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the OD at 345 nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.


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