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ACE-2 Substrate, Fluorogenic

A fluorogenic ACE-2 (Angiotensin I-converting enzyme 2) substrate
Catalog #: B2726
SKU-Size Size Price Qty
B2726-1 1 mg
B2726-5 5 mg
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Product Details

Alternate Name Mca-APK(Dnp), Mca-Ala-Pro-Lys(Dnp)-OH [Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl], ACE2 Substrate
Peptide Sequence Mca-Ala-Pro-Lys(Dnp)-OH
Appearance Yellow solid
CAS # 305336-82-7
Molecular Formula C₃₂H₃₆N₆O₁₂
Molecular Weight 696.7
Purity ≥95% by HPLC
Solubility ~2 mg/ml DMSO
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp)-OH (Cat. No. B2717), this substrate is not cleaved by caspases. This peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. This substrate is useful for inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm.

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