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Acalabrutinib

A potent, selective and irreversible inhibitor of Bruton’s tyrosine kinase (BTK)
Catalog #: B1193

In stock

SKU-Size Size Price Qty
B1193-5 5 mg
$95.00
B1193-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide; ACP-196
Appearance Yellow Solid
CAS # 1420477-60-6
Molecular Formula C₂₆H₂₃N₇O₂ 
Molecular Weight 465.52
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5
InChi InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1
InChi Key WDENQIQQYWYTPO-IBGZPJMESA-N
PubChem CID 71226662
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acalabrutinib (ACP-196) is an orally available, selective irreversible inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. It is a second generation BTK inhibitor with improved pharmacological properties with better plasma exposure, oral absorption and shorter half-life. It prevents the activation of B-cell antigen receptor (BCR) signaling pathway, thus preventing B-cell activation and BTK mediated activation of downstream survival pathways.


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