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A Group I caspase substrate
Catalog #: B2282
SKU-Size Size Price Qty
B2282-5 5 mg
B2282-25 25 mg
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Product Details

Alternate Name Caspase-1 substrate (chromogenic), Caspase-5 substrate (chromogenic); Ac-Trp-Glu-His-Asp-paranitroanilide
Peptide Sequence Ac-Trp-Glu-His-Asp-pNA
Appearance Yellow solid
Molecular Formula C₃₄H₃₇N₉O₁₁
Molecular Weight 747.70
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
InChi InChI=1S/C34H37N9O11/c1-18(44)38-26(12-19-15-36-24-5-3-2-4-23(19)24)33(51)40-25(10-11-29(45)46)31(49)41-27(13-21-16-35-17-37-21)34(52)42-28(14-30(47)48)32(50)39-20-6-8-22(9-7-20)43(53)54/h2-9,15-17,25-28,36H,10-14H2,1H3,(H,35,37)(H,38,44)(H,39,50)(H,40,51)(H,41,49)(H,42,52)(H,45,46)(H,47,48)
PubChem CID 44135315
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ac-WEHD-pNA is a useful colorimetric substrate for group I caspases (caspase-1, -4, and -5). Cleavage of the substrate by a caspase releases pNA, which can be detected by its absorbance at 405 nm.

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