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A potent ERβ agonist
Catalog #: B2980
SKU-Size Size Price Qty
B2980-1 1 mg
B2980-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Appearance White solid
CAS # 1421854-16-1
Molecular Formula C₁₈H₁₇F₃O
Molecular Weight 306.32
Purity 95%
Solubility ~30 mg/ml in DMSO
InChi InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2
PubChem CID 71245042
MDL Number MFCD28502295
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated with increased risk of Alzheimer’s disease. AC-186 exhibits gender selective neuroprotection in male animals in a rat model of Parkinson’s disease. AC-186 in combination with ACP-105 increases the amyloid-β degrading enzymes neprilysin and insulin-degrading enzyme, decreases amyloid-β levels in the brain as well as improves cognition in a mouse model of Alzheimer’s Disease.

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