Product Details
| Alternate Name | 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide dihydrochloride; Veliparib |
|---|---|
| Appearance | Coloreless to white crystalline solid |
| CAS # | 912445-05-7 |
| Molecular Formula | C₁₃H₁₆N₄O.2HCl |
| Molecular Weight | 317.21 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO and H₂O |
| SMILES | CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N |
| InChi | InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1 |
| InChi Key | JNAHVYVRKWKWKQ-CYBMUJFWSA-N |
| PubChem CID | 11960529 |
| MDL Number | MFCD16661206 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.
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