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ABT-888

A PRP-1 and PARP-2 inhibitor
Catalog #: 1620
SKU-Size Size Price Qty
1620-1 1 mg
$155.00
1620-5 5 mg
$520.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide dihydrochloride; Veliparib
Appearance Coloreless to white crystalline solid
CAS # 912445-05-7
Molecular Formula C₁₃H₁₆N₄O.2HCl
Molecular Weight 317.21
Purity ≥98% by HPLC
Solubility DMSO and H₂O
SMILES CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
InChi InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
InChi Key JNAHVYVRKWKWKQ-CYBMUJFWSA-N
PubChem CID 11960529
MDL Number MFCD16661206
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.


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