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A VEGFR and PDGFR kinase inhibitor
Catalog #: 1615
SKU-Size Size Price Qty
1615-1 1 mg
1615-5 5 mg
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Product Details

Alternate Name Linifanib
Appearance Crystalline solid
CAS # 796967-16-3
Molecular Formula C₂₁H₁₈FN₅O
Molecular Weight 375.41
Purity ≥99%
Solubility DMSO
InChi InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
PubChem CID 11485656
MDL Number MFCD11840918
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC₅₀ value of 4 nM), but has much less activity (IC₅₀ values >1 µM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC₅₀ values of 2, 4 and 7 nM for PDGFRβ, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC₅₀ for human endothelial cells).

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