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ABT-494

A potent and selective Janus kinase JAK-1 inhibitor
Catalog #: B1947
SKU-Size Size Price Qty
B1947-5 5 mg
$195.00
B1947-25 25 mg
$775.00
More Sizes Get Quote

Product Details

Alternate Name (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide; Upadacitinib
Appearance Crystalline solid
CAS # 1310726-60-3
Molecular Formula C₁₇H₁₉F₃N₆O
Molecular Weight 380.37
Purity ≥98% by HPLC
Solubility DMSO
SMILES CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F
InChi InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
InChi Key WYQFJHHDOKWSHR-MNOVXSKESA-N
PubChem CID 58557659
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ABT-494 is a potent and selective Janus kinase JAK-1 inhibitor (IC₅₀ = 43 nM). ABT-494 is 74-fold more selective for JAK-1 over JAK-2 and 58-fold more selective for JAK-1 over JAK-3.


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