Product Details
| Alternate Name | (R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide; Asciminib |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1492952-76-7 |
| Molecular Formula | C₂₀H₁₈ClF₂N₅O₃ |
| Molecular Weight | 449.84 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | C1CN(CC1O)C2=NC=C(C=C2C3=CC=NN3)C(=O)NC4=CC=C(C=C4)OC(F)(F)Cl |
| InChi | InChI=1S/C20H18ClF2N5O3/c21-20(22,23)31-15-3-1-13(2-4-15)26-19(30)12-9-16(17-5-7-25-27-17)18(24-10-12)28-8-6-14(29)11-28/h1-5,7,9-10,14,29H,6,8,11H2,(H,25,27)(H,26,30)/t14-/m1/s1 |
| InChi Key | VOVZXURTCKPRDQ-CQSZACIVSA-N |
| PubChem CID | 72165228 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
ABL-001 is a potent allosteric inhibitor of BCR-ABL. ABL001 binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation. ABL001 prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of CML (chronic myeloid leukemia).
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