A potent allosteric inhibitor of BCR-ABL
Catalog #: B1949 | abID:

Product Details

Alternate Name (R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide; Asciminib
Appearance Crystalline solid
CAS # 1492952-76-7
Molecular Formula C₂₀H₁₈ClF₂N₅O₃
Molecular Weight 449.84
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C20H18ClF2N5O3/c21-20(22,23)31-15-3-1-13(2-4-15)26-19(30)12-9-16(17-5-7-25-27-17)18(24-10-12)28-8-6-14(29)11-28/h1-5,7,9-10,14,29H,6,8,11H2,(H,25,27)(H,26,30)/t14-/m1/s1
PubChem CID 72165228
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ABL-001 is a potent allosteric inhibitor of BCR-ABL. ABL001 binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation. ABL001 prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of CML (chronic myeloid leukemia).

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