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Abexinostat

A broad-spectrum histone deacetylase (HDAC) inhibitor
Catalog #: B2202

In stock

SKU-Size Size Price Qty
B2202-5 5 mg
$115.00
B2202-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 3-(dimethylaminomethyl)-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide; CRA-024781; PCI-24781
Appearance White to off-white solid
CAS # 783355-60-2
Molecular Formula C₂₁H₂₃N₃O₅
Molecular Weight 397.42
Purity ≥96% by HPLC
Solubility DMSO
SMILES CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO
InChi InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)
InChi Key MAUCONCHVWBMHK-UHFFFAOYSA-N
PubChem CID 11749858
MDL Number MFCD10565969
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Abexinostat is a broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. It inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Abexinostat has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs).


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