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ABCG1 Antibody (Center)

Polyclonal Antibody to detect ABCG1 in human samples
Catalog #: 6705
$245.00

Product Details

Cat # +Size 6705-100
Size 100 μl
Antibody Target ABCG1
Alternate Name ABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-387 amino acids from the central region of human ABCG1.
Accession # P45844
Gene ID ABCG1
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Species Reactivity Human
Application Western blot, IHC, FACS
Positive Control Western blot: 293 cell lysate, IHC: human hepatocarcinoma, FACS: HepG2 cells
Application & Usage Western blot: ~1:1000, FACS: ~1:10–1:50, IHC: ~1:50-1:100.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ABCG1 (ATP-binding cassette sub-family G member 1), a transporter protein primarily involved in macrophage lipid homeostasis, localizes to intracellular compartments associated with ER /Golgi membranes, and its expression is highest in macrophage-rich tissue such as spleen, lung, and thymus as well as in brain. ABCG1 form heterodimers with heterologous ABCG partners and functional heterodimerization with ABCG4 has been of great interest because brain cells, mainly neurons and astrocytes, depict high expression of both transporters. ABCG1 is involved in the export of a variety of lipids (in conjunction with ABCA1) including cholesterol and phospholipids from macrophages to HDL. Macrophage lipid export is the first step in the reverse cholesterol transport pathway that exports cholesterol from peripheral cells to circulating lipoproteins for eventual excretion via liver. Cholesterol export to lipoprotein acceptors is compromised in macrophage foam cells, one of the early hallmarks of atherosclerosis. Moreover, ABCG1 plays role in T cells/inflammation, brain lipid homeostasis and its expression increases in macrophages of Tangier disease patients.


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