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AAL-993

A potent VEGFR inhibitor
Catalog #: 2740
SKU-Size Size Price Qty
2740-2 2 mg
$85.00
2740-10 10 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide
Appearance Light yellow solid
CAS # 269390-77-4
Molecular Formula C₂₀H₁₆F₃N₃O
Molecular Weight 371.36
Purity ≥98% by TLC
Solubility DMSO (>25 mg/ml) or EtOH (~15 mg/ml)
SMILES C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3
InChi InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
InChi Key BLAFVGLBBOPRLP-UHFFFAOYSA-N
PubChem CID 6398883
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC₅₀ = 130 nM), VEGFR-2 (IC₅₀ = 23 nM) and VEGFR-3 (IC₅₀ = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model).


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