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A77 1726

Physiologically active metabolite of the immunosuppressive drug leflunomide
Catalog #: 1973

In stock

SKU-Size Size Price Qty
1973-5 5 mg
$90.00
1973-25 25 mg
$330.00
More Sizes Get Quote

Product Details

Alternate Name N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Appearance White solid
CAS # 108605-62-5
Molecular Formula C₁₂H₉F₃N₂O₂
Molecular Weight 270.21
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
InChi InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
InChi Key UTNUDOFZCWSZMS-YFHOEESVSA-N
PubChem CID 54684141
MDL Number MFCD00910058
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of COX-2 in vitro and in vivo.


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