A77 1726

Physiologically active metabolite of the immunosuppressive drug leflunomide
Catalog #: 1973 | abID: ab141480

Product Details

abID ab141480
Alternate Name N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Teriflunomide; Flucyamide
Appearance White solid
CAS # 108605-62-5
Molecular Formula C₁₂H₉F₃N₂O₂
Molecular Weight 270.21
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
PubChem CID 54684141
MDL Number MFCD00910058
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of COX-2 in vitro and in vivo.

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