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Product Details
| Alternate Name | N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide |
|---|---|
| Appearance | White solid |
| CAS # | 108605-62-5 |
| Molecular Formula | C₁₂H₉F₃N₂O₂ |
| Molecular Weight | 270.21 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O |
| InChi | InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7- |
| InChi Key | UTNUDOFZCWSZMS-YFHOEESVSA-N |
| PubChem CID | 54684141 |
| MDL Number | MFCD00910058 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of COX-2 in vitro and in vivo.
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