Product Details
| abID | ab142092 |
|---|---|
| Cat # +Size | 1725-1 |
| Size | 1 mg |
| Alternate Name | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-p yrazole-1-carbothioamide |
| Appearance | Pale yellow solid |
| CAS # | 909910-43-6 |
| Molecular Formula | C₂₅H₁₉N₅S |
| Molecular Weight | 421.52 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 |
| InChi | InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31) |
| InChi Key | HIJMSZGHKQPPJS-UHFFFAOYSA-N |
| PubChem CID | 16218924 |
| MDL Number | MFCD08705403 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC₅₀ values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs).
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Chen Dong, Derivation of trophoblast stem cells from naïve human pluripotent stem cells. eLife., Feb. 2020; 32048992.
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