A 83-01

A TGF-β type I receptor ALK5 kinase inhibitor
Catalog #: 1725 | abID: ab142092

Product Details

abID ab142092
Cat # +Size 1725-1
Size 1 mg
Alternate Name 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-p yrazole-1-carbothioamide
Appearance Pale yellow solid
CAS # 909910-43-6
Molecular Formula C₂₅H₁₉N₅S
Molecular Weight 421.52
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
PubChem CID 16218924
MDL Number MFCD08705403
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC₅₀ values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs).

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Chen Dong, Derivation of trophoblast stem cells from naïve human pluripotent stem cells. eLife., Feb. 2020; 32048992.
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