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A potent and selective Nav1.8 sodium channel blocker
Catalog #: B3214
SKU-Size Size Price Qty
B3214-5 5 mg
B3214-25 25 mg
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Product Details

Alternate Name 5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide; A803467
Peptide Sequence N/A
Appearance Off-white solid
CAS # 944261-79-4
Molecular Formula C₁₉H₁₆ClNO₄
Molecular Weight 357.79
Purity ≥98% by HPLC
Solubility >30 mg/ml DMSO
InChi InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
PubChem CID 16038374
MDL Number MFCD10574689
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A-803467 is a selctive a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocks human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥1 μM.

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