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Product Details
| Alternate Name | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine |
|---|---|
| Appearance | Off-white solid |
| CAS # | 1527503-11-2 |
| Molecular Formula | C₁₉H₂₇N₃O₂ |
| Molecular Weight | 329.44 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>25 mg/ml) |
| SMILES | NC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3 |
| InChi | InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21) |
| InChi Key | BKCDJTRMYWSXMC-UHFFFAOYSA-N |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM.
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