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A-366

A potent and selective G9a/GLP histone lysine methyltransferase inhibitor
Catalog #: 2859

In stock

SKU-Size Size Price Qty
2859-1 1 mg
$105.00
2859-5 5 mg
$385.00
More Sizes Get Quote

Product Details

Alternate Name 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Appearance Off-white solid
CAS # 1527503-11-2
Molecular Formula C₁₉H₂₇N₃O₂
Molecular Weight 329.44
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES NC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3
InChi InChI=1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChi Key BKCDJTRMYWSXMC-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM.


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