A potent and selective SUV420H1/H2 inhibitor
Catalog #: B3252 | abID:

Product Details

Alternate Name Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
Appearance Crystalline solid
CAS # 1982372-88-2
Molecular Formula C₁₈H₁₆Cl₂N₄
Molecular Weight 359.25
Purity ≥98% by HPLC
Solubility >7 mg/ml DMSO
InChi InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
PubChem CID 117072548
MDL Number MFCD29924807
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A-196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Displays 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).

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