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A-839977

A potent P2X7 antagonist
Catalog #: B2973
SKU-Size Size Price Qty
B2973-5 5 mg
$125.00
B2973-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine
Appearance White solid
CAS # 870061-27-1
Molecular Formula C₁₉H₁₄Cl₂N₆O
Molecular Weight 413.26
Purity 98%
Solubility Soluble in DMSO
SMILES C1=CC=C(C(=C1)CNC2=NN=NN2C3=C(C(=CC=C3)Cl)Cl)OC4=CC=CC=N4
InChi InChI=1S/C19H14Cl2N6O/c20-14-7-5-8-15(18(14)21)27-19(24-25-26-27)23-12-13-6-1-2-9-16(13)28-17-10-3-4-11-22-17/h1-11H,12H2,(H,23,24,26)
InChi Key GMVNBKZQJFRFAR-UHFFFAOYSA-N
PubChem CID 53325875
MDL Number MFCD19690959
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A-839977 is a potent antagonist of the purinergic receptor P2X subtype 7 (P2X7). A-839977 potently blocks BzATP-induced calcium influx at recombinant human, rat and mouse P2X7 receptors with IC₅₀ values of 20 nM, 42 nM and 150 nM respectively. It also potently blocks agonist-induced YO-PRO uptake and IL-1β release from differentiated human THP-1 cells. It shows antihyperalgesic and antinociceptive effects in animal models of inflammatory pain.


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