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A-1155463

A highly potent and selective BCL-XL inhibitor.
Catalog #: B1821

In stock

SKU-Size Size Price Qty
B1821-5 5 mg
$125.00
B1821-25 25 mg
$495.00

Product Details

Alternate Name 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid
Appearance Crystalline solid
CAS # 1235034-55-5 
Molecular Formula C₃₅H₃₂FN₅O₄S₂ 
Molecular Weight 669.79
Purity ≥98% by HPLC
Solubility DMSO
SMILES CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=CC=CC(=C4C3)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F
InChi InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)
InChi Key SOYCFODXNRVBTI-UHFFFAOYSA-N
PubChem CID 59447577
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is more potent against BCL-XL-dependent cell lines relative to WEHI-539 (Cat. No. B1819), while possessing none of its inherent pharmaceutical liabilities.


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