DYRK Family of Kinases
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. The DYRK family consists of 5 members divided into two classes: Class I is comprised of DYRK1A and DYRK1B, whereas class II is comprised of DYRK2, DYRK3, and DYRK4. All DYRK proteins studied to date share common structural, biochemical, and functional properties with their ancestors in yeast. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease. BioVision offers a variety of products for research involving DYRK family.
Click on the targets for product details.
- increased growth signaling
Increased Growth Signaling product list:
• Human CellExp™ VEGF 121, Human Recombinant (Cat#: 6484)
• p130Cas, Human Recombinant (Cat#: P1634)
• XRK3F2 (Cat#: B2381)
More... - angiogenesis
Angiogenesis product list:
• Angiogenesis (Tube Formation) Assay (Cat#:K905)
• Withaferin A (Cat#: B2716)
• BioSim™ anti-Bevacizumab (Human) ELISA Kit (Cat#: E4389)
More... - regulation of cell proliferation
Regulation of Cell Proliferation product list:
• EZClick™ Global RNA Synthesis Assay Kit (Cat#: K462)
• EZClick™ Global RNA Synthesis Assay Kit (FACS/Microscopy), Red Fluorescence (Cat#: K718)
• Human CellExp™ PD-L1 /CD274 /B7-H1, mouse recombinant (Cat#: 7428) - Migration and Tissue Invasion
Migration and Tissue Invasion product list:
• Allicin (Cat#: B2960)
• MET, Active (Cat#: 7771) - Altered Metabolism
Altered Metabolism product list:
• DASA-58 (Cat#: B2163)
• CT-2584 (Cat#: B1182) - DYRK1A
DYRK1A product list:
• GNF-4877 (Cat#: B2720)
• GSK-626616 (Cat#: B2452)
• DIRK1A/1B inhibitor AnnH31 (Cat#: B3287)
More... - DYRK2
DYRK2 product list:
• GSK-626616 (Cat#: B2452)
• LDN-192960 hydrochloride (Cat#: B3285)
• DIRK1A/1B inhibitor AnnH31 (Cat#: B3287)
More... - DYRK3
DYRK3 product list:
• A-443654 (Cat#: B3277) - DYRK4
DYRK4 product list:
• Harmine (Cat#: 2561) - actin
Actin product list:
• Actin Polymerization/ Depolymerization Assay Kit (Fluorometric) (Cat#: K457)
• Anti-Beta Actin Antibody (4F7) (Cat#: A1031)
• Actin, pyrene labeled, Rabbit Muscle (Cat#: M1319)
More... - MAL
MAL product list:
• Anti-CD8A Antibody (C8/468) (Cat#: A1570)
• Anti-Human CD8a PE Antibody (OKT8) (Cat#: A1583)
• CD8 FITC Monoclonal Antibody (Clone OKT-8) (Cat#: 6954)
More... - GLI2
GLI2 product list:
• HPI-1 (Cat#: 2410) - GLI1
GLI1 product list:
• Anti-GLI1 Antibody (Cat#: A1224)
• GANT61 (Cat#: 1892)
• HPI-1 (Cat#: 2410)
More... - SMO
SMO product list:
• Smo Antagonist, SA10 (Cat#: 2159)
• Smo Antagonist, SA9 (Cat#: 2155)
• Smo Agonist, SAG (Cat#: 1939)
More... - Hh
Hh product list:
• Hh Signaling Pathway Antagonist (Cat#: 1659)
• Hh-Ag1.5 (Cat#: B2160)
• DiscoveryPak™ Hedgehog (Hh) Signaling Pathway Inhibitors Set (Cat#: K868)
More... - PTCH1
PTCH1 product list:
• Anti-SHH Antibody (Cat#: A1381)
• Anti-SHH Antibody (Cat#: A1017)
• Smo Antagonist, SA1 (Cat#: 2154)
More... - Myogenesis
Factor I product list:
• Anti-CD164 Antibody (Cat#: A1242)
• Notch-1, mouse recombinant (Cat#: 7530)
• Notch-2, mouse recombinant (Cat#: 7531)
More... - Down Syndrome
Down Syndrome product list:
•Anti-SIM2 Antibody (Cat#: A1918)
• Human CellExp™ Cathepsin S, human recombinant (Cat#: 7277)
Leucettine L41 (Cat#: 2617) - Cell Survival
Cell Survival product list:
• EZSolution™ Thiazovivin (Cat#: 1736)
• EZSolution™ Thiazovivin, Sterile-Filtered (Cat#: 1993)
• StemRegenin 1 (Cat#: 1967)
More... - neurogenesis
neurogenesis product list:
• Neurodazine (Cat#: 2568)
• Kenpaullone (Cat#: 1904)
• P7C3-A20 (Cat#: 2850)
More... - Neuroblast Proliferation
Neuroblast Proliferation product list:
• Anti-Frizzled 9 Antibody (Cat#: A1633)
