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8-Br-cAMP

A PKA activator
Catalog #: 1837

In stock

SKU-Size Size Price Qty
1837-5 5 mg
$65.00
1837-25 25 mg
$185.00
More Sizes Get Quote

Product Details

Alternate Name 8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8- bromoadenosine- 3', 5'-Monophosphate
Appearance White to off-white solid
CAS # 76939-46-3
Molecular Formula C₁₀H₁₀BrN₅O₆P. Na
Molecular Weight 430.08
Purity ≥98% by TLC
Solubility H₂O (~100 mg/ml)
SMILES C1C2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]
InChi InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1
InChi Key DMRMZQATXPQOTP-UHFFFAOYSA-M
PubChem CID 23712387
MDL Number MFCD00005844
Handling Protect from moisture and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. Also recently shown to improve the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells 2-fold.


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