You have no items in your shopping cart.
Product Details
| Alternate Name | 3-(3-aminopropoxy)-N-[2-[3-[(4-chloro-2-hydroxyphenyl)carbamoyl]naphthalen-2-yl]oxyethyl]naphthalene-2-carboxamide, hydrochloride; 3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride; CREB 666-15; CREB Inhibitor; CBP-CREB Interaction Inhibitor II; Compound 3i |
|---|---|
| Appearance | White solid |
| CAS # | 1433286-70-4 |
| Molecular Formula | C₃₃H₃₁Cl₂N₃O₅ |
| Molecular Weight | 620.52 |
| Purity | 98.65% |
| Solubility | ~30 mg/ml in DMSO |
| SMILES | C1=CC=C2C=C(C(=CC2=C1)C(=O)NCCOC3=CC4=CC=CC=C4C=C3C(=O)NC5=C(C=C(C=C5)Cl)O)OCCCN.Cl |
| InChi | InChI=1S/C33H30ClN3O5.ClH/c34-25-10-11-28(29(38)20-25)37-33(40)27-17-22-7-2-4-9-24(22)19-31(27)42-15-13-36-32(39)26-16-21-6-1-3-8-23(21)18-30(26)41-14-5-12-35;/h1-4,6-11,16-20,38H,5,12-15,35H2,(H,36,39)(H,37,40);1H |
| InChi Key | LELLCPHHYHLWBH-UHFFFAOYSA-N |
| PubChem CID | 71566396 |
| MDL Number | MFCD30182343 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
666-15 is a potent and selective inhibitor of cyclic adenosine monophosphate response element binding protein (CREB)-mediated gene transcription with an IC₅₀ of 81 nM. The IC₅₀ values for inhibiting the growth of A549, MCF-7, MDA-MB-231, MDA-MB-468 cell lines are 0.47 μM, 0.31 μM, 0.073 μM, 0.046 μM respectively. It is a weak inhibitor of CREB-CBP (CREB-binding protein) interaction with an IC₅₀ of 18.27 μM. Intraperitoneal injection of 666-15 at 10 mg/kg/day, 5 days per week for 5 weeks suppresses tumor growth in an in vivo MDA-MB-468 xenograft model.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
