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5-Nitroso-8-quinolinol

An inhibitor of HDAC
Catalog #: B2825
SKU-Size Size Price Qty
B2825-5 5 mg
$55.00
B2825-25 25 mg
$195.00
More Sizes Get Quote

Product Details

Alternate Name 5-Nitroso-8-hydroxyquinoline, 5-Nitrosoquinolin-8-ol, 5-Nitroso-8-cinnolinol, 5-Nitrosooxine, 8-Hydroxy-5-nitrosoquinoline, (5Z)-5-hydroxyimino-quinolin-8-one, (5Z)-5,8-quinolinedione 5-oxime, NSC 3852
Appearance Crystalline solid
CAS # 3565-26-2
Molecular Formula C₉H₆N₂O₂
Molecular Weight 174.16
Purity ≥95%
Solubility ~1 mg/ml in DMF
~2 mg/ml in DMSO
SMILES C1=CC2=C(C=CC(=C2N=C1)O)N=O
InChi InChI=1S/C9H6N2O2/c12-8-4-3-7(11-13)6-2-1-5-10-9(6)8/h1-5,12H
InChi Key RZWRYPGAUIOOMK-UHFFFAOYSA-N
PubChem CID 19103
MDL Number MFCD00041862
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

5-Nitroso-8-quinolinol is a quinoline inhibitor of histone deacetylase (HDAC). It inhibits HDAC activity in vitro and causes reactive oxygen species, DNA damage and apoptosis in MCF-7 breast cancer cells at a concentration of 10 μM. It exhibits anticancer activity in mice. It inhibits growth of Toxoplasma gondii with an EC₅₀ of 80 nM.


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