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5-Lipoxygenase Inhibitor Screening Kit (Fluorometric)

Highly Sensitive; Includes Zileuton as inhibitor control
Catalog #: K980
$565.00

Product Details

Cat # +Size K980-100
Size 100 assays
Detection Method Fluorescence (Ex/Em 500/536 nm)
Species Reactivity Human
Applications • Screening of potential inhibitors of 5-lipoxygenase
Features & Benefits • Simple procedure; takes only ~40 min
• Fast and convenient
Kit Components • LOX Assay Buffer
• LOX Probe
• LOX Substrate
• Zileuton
• 5-LOX Enzyme
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

5-Lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase that converts unsaturated fatty acids to epoxides; for example the synthesis of leukotrienes from arachidonic acid. It is involved in processes like cell proliferation, differentiation and inflammation and has been implicated in inflammation and hyper proliferation mediated diseases like asthma, rheumatoid arthritis and cancer. Research for identifying potential remedies for such diseases involves the identification of inhibitors of 5-lipoxygenase. BioVision’s 5-Lipoxygenase Inhibitor Screening Kit uses Zileuton, a well-known 5-lipoxygenase inhibitor as positive control, and provides a simple and fast method to screen/ characterize potential 5-lipoxygenase inhibitors


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What is an appropriate solvent to dissolve the test compounds?
You can dissolve your test compound in any solvent that is recommended for your compound. Please include a solvent control in your assay. We do not expect the solvents to have a significant impact since they are used in negligible amounts.