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Anti-5-Hydroxytryptamine Receptor 1A Antibody

Polyclonal antibody against EDG7
Catalog #: A1059
$365.00

Product Details

Cat # +Size A1059-100
Size 100 µl
Antibody Target Serotonin
Alternate Name 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A, Htr1a, 5ht1a
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Peptide KKSLNGQPGSGDWRRC, corresponding to amino acid residues 251-266 of rat 5-Hydroxytryptamine Receptor 1A (Accession P19327). 3rd intracellular loop.Will not recognize human 5-Hydroxytryptamine Receptor 1A.
Accession # P19327
Gene ID 24473
Appearance Colourless liquid
Formulation In PBS, pH 7.4, 1% BSA, 0.05% NaN3.
Purification Affinity purified
Species Reactivity Mouse, Rat
Application Western blot, IHC
Positive Control Western blot, IHC
Application & Usage WB: 1:200-1:2000, IHC: 1:100
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Serotonin [5-hydroxytryptamine (5-HT1)] is an important neurotransmitter in the CNS that exerts its neuronal activity via 5-HT receptors. 5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-Protein Coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels. The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1e AND 5-HT1F) which share 41-63% overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation. The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species. Activation of 5-HT1A receptor decreases blood pressure and heart rate, involved in learning, memory, relieving anxiety and depression. 5-Hydroxytryptamine Receptor


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