A methyltransferase inhibitor
Catalog #: B1053 | abID:

Product Details

Alternate Name 5'-S-methyl-5'-thio-adenosine; Methylthioadenosine; MTA; NSC 335422; Vitamil L2
Appearance White to off-white solid
CAS # 2457-80-9
Molecular Formula C₁₁H₁₅N₅O₃S
Molecular Weight 297.3
Purity ≥98%
Solubility DMSO (~25 mg/ml)
InChi InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
PubChem CID 439176
MDL Number MFCD00010533
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. Acts as a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.

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