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5-Aza-2'-deoxycytidine

An epigenetic modifier
Catalog #: 1754

In stock

SKU-Size Size Price Qty
1754-10 10 mg
$110.00
1754-50 50 mg
$385.00
More Sizes Get Quote

Product Details

Alternate Name 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine
Appearance White to off-white solid
CAS # 2353-33-5
Molecular Formula C₈H₁₂N₄O₄
Molecular Weight 228.08
Purity ≥98% by HPLC
Solubility DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)
SMILES C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
InChi InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
InChi Key XAUDJQYHKZQPEU-KVQBGUIXSA-N
PubChem CID 451668
MDL Number MFCD00043011
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.


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