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Product Details
| Alternate Name | 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 2353-33-5 |
| Molecular Formula | C₈H₁₂N₄O₄ |
| Molecular Weight | 228.08 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (25 mg/ml), 50% acetic acid (25 mg/ml) |
| SMILES | C1C(C(OC1N2C=NC(=NC2=O)N)CO)O |
| InChi | InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1 |
| InChi Key | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| PubChem CID | 451668 |
| MDL Number | MFCD00043011 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.
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