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4-Iodo-SAHA

A hydrophobic derivative of HDAC inhibitor SAHA
Catalog #: B2800
SKU-Size Size Price Qty
B2800-10 10 mg
$75.00
B2800-50 50 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name 4-iodo-SAHA, 4-Iodo Suberoylanilide Hydroxamic Acid, N1-hydroxy-N8-(4-iodophenyl)octanediamide, N~1~-Hydroxy-N~8~-(4-iodophenyl)octanediamide
Appearance Crystalline solid
CAS # 1219807-87-0
Molecular Formula C₁₄H₁₉IN₂O₃
Molecular Weight 390.22
Purity ≥98%
Solubility ~ 30 mg/ml in DMSO and DMF, ~ 0.2 mg/ml in Ethanol
SMILES C1=CC(=CC=C1NC(=O)CCCCCCC(=O)NO)I
InChi 1S/C14H19IN2O3/c15-11-7-9-12(10-8-11)16-13(18)5-3-1-2-4-6-14(19)17-20/h7-10,20H,1-6H2,(H,16,18)(H,17,19)
InChi Key BYVHZKAHBXINPL-UHFFFAOYSA-N
PubChem CID 46205754
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived cell lines, HT29 colon-derived cell lines, leukemia-derived U937 tumor cell line, JA16, HL60 and K562 cell lines with EC50 values of 1.1 μM, 0.95 μM, 0.12 μM, 0.24 μM, 0.85 μM and 1.3 μM, respectively. It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA.


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