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4-Hydroxyquinazoline

An inhibitor of PARP
Catalog #: B3148
SKU-Size Size Price Qty
B3148-100 100 mg
$60.00
B3148-500 500 mg
$240.00
More Sizes Get Quote

Product Details

Alternate Name 4-HQN; Quinazolin-4-ol
Appearance White to Light yellow powder
CAS # 491-36-1
Molecular Formula C₈H₆N₂O
Molecular Weight 146.15
Purity ≥ 98%
Solubility ~1 mg/ml in DMSO or DMF
SMILES C1=CC=C2C(=C1)C(=O)NC=N2
InChi InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChi Key QMNUDYFKZYBWQX-UHFFFAOYSA-N
PubChem CID 135408753
MDL Number MFCD00511302
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

4-Hydroxyquinazoline is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 9.5 μM. 4-hydroxyquinazoline improves the recovery of high-energy phosphates (ATP, creatine phosphate) and accelerates the reutilization of inorganic phosphate formed during ischemia. The quinazoline structure is an important pharmacophore possessing a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.


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