Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


An inositol requiring enzyme 1 α (IRE1α) inhibitor
Catalog #: B2495
SKU-Size Size Price Qty
B2495-5 5 mg
B2495-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name IRE1 Inhibitor III; 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Appearance White to off-white solid
CAS # 14003-96-4
Molecular Formula C₁₁H₈O₄
Molecular Weight 204.18
Purity ≥98% by HPLC
Solubility >25 mg/ml in DMSO
InChi InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3
PubChem CID 12934390
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


4µ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). It blocks substrate access to the active site of IRE1α and inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.