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3-Deazaneplanocin A

A lysine methyltransferase EZH2 (KMT63) inhibitor
Catalog #: 2060

In stock

SKU-Size Size Price Qty
2060-250 250 µg
$80.00
2060-1000 1 mg
$265.00
More Sizes Get Quote

Product Details

Alternate Name DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol
Appearance Off-white solid
CAS # 102052-95-9
Molecular Formula C₁₂H₁₄N₄O₃
Molecular Weight 262.26
Purity ≥98%
Solubility DMSO (20 mg/ml) or EtOH (1 mg/ml)
SMILES C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
InChi InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
InChi Key OMKHWTRUYNAGFG-IEBDPFPHSA-N
PubChem CID 73087
MDL Number MFCD12545899
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.


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