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3-Deazaneplanocin A hydrochloride

A lysine methyltransferase EZH2 (KMT63) inhibitor
Catalog #: 2444
SKU-Size Size Price Qty
2444-250 250 µg
2444-1000 1 mg
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Product Details

Alternate Name DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol hydrochloride
Appearance White to off-white solid
CAS # 120964-45-6
Molecular Formula C₁₂H₁₄N₄O₃. HCl
Molecular Weight 298.73
Purity ≥98% by HPLC
Solubility H₂O (~5 mg/ml)
InChi InChI=1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H
PubChem CID 358176
MDL Number MFCD18782644
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.

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