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2-Hexyl-4-Pentynoic Acid

An inhibitor of HDACs
Catalog #: B2834
SKU-Size Size Price Qty
B2834-100 100 mg
$65.00
B2834-500 500 mg
$145.00
More Sizes Get Quote

Product Details

Alternate Name 2-prop-2-ynyloctanoic acid; 2-Propargyloctanoic Acid
Appearance Oil
CAS # 96017-59-3
Molecular Formula C₁₁H₁₈O₂
Molecular Weight 182.26
Purity ≥95%
Solubility ~20 mg/ml in DMSO
~16 mg/ml in DMF
~33 mg/ml in Ethanol
~2mg/ml in PBS, pH 7.2
SMILES CCCCCCC(CC#C)C(=O)O
InChi InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)
InChi Key DUQSBRQHALCSLC-UHFFFAOYSA-N
PubChem CID 175664
MDL Number MFCD00946863
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a concentration of 5 μM in cerebellar granule cells and increases HSP70-1a and HSP70-1b mRNA levels at 50 μM. It is neuroprotective against glutamate-induced excitotoxicity.


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B2834-100 is supplied in Oil. Could you please tell me how to make the stock in DMSO?
2-Hexyl-4-Pentynoic Acid is supplied as neat oil. The concentration of neat oil is 100% (not corrected for purity) and weight per volume is the density rather than concentration. Solubility limit in DMSO is approximately 20 mg/ml. We recommend taring the weight of a suitable container, and weighing a given amount of product into the container so that the volume of DMSO required will be appropriate for the volume of the container and the desired solubility. If you were to weigh 40 mg of the neat oil, dissolving to a final volume of 2 mL, for example, would result in a 20 mg/ml stock solution.