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2-Hexyl-4-Pentynoic Acid

An inhibitor of HDACs
Catalog #: B2834
SKU-Size Size Price Qty
B2834-100 100 mg
$65.00
B2834-500 500 mg
$145.00
More Sizes Get Quote

Product Details

Alternate Name 2-prop-2-ynyloctanoic acid; 2-Propargyloctanoic Acid
Appearance Oil
CAS # 96017-59-3
Molecular Formula C₁₁H₁₈O₂
Molecular Weight 182.26
Purity ≥95%
Solubility ~20 mg/ml in DMSO
~16 mg/ml in DMF
~33 mg/ml in Ethanol
~2mg/ml in PBS, pH 7.2
SMILES CCCCCCC(CC#C)C(=O)O
InChi InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)
InChi Key DUQSBRQHALCSLC-UHFFFAOYSA-N
PubChem CID 175664
MDL Number MFCD00946863
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a concentration of 5 μM in cerebellar granule cells and increases HSP70-1a and HSP70-1b mRNA levels at 50 μM. It is neuroprotective against glutamate-induced excitotoxicity.


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