A competitive inhibitor of glucose metabolism.
Catalog #: B1048 | abID:

Product Details

Alternate Name 2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Appearance White to off-white solid
CAS # 154-17-6
Molecular Formula C₆H₁₂O₅
Molecular Weight 164.16
Purity ≥98% GC
Solubility H2O (>15 mg/ml) or DMSO (>15 mg/ml)
InChi InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1
PubChem CID 439268
MDL Number MFCD00151328
Handling Protect from air and moisture
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.

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