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2'-Deoxy-6-thioguanosine

An anticancer agent
Catalog #: 2828

In stock

SKU-Size Size Price Qty
2828-5 5 mg
$145.00
2828-25 25 mg
$585.00
More Sizes Get Quote

Product Details

Alternate Name 2'-Deoxy-6-thio-D-guanosine;6-Thio-2'-deoxyguanosine; 6-thio-DG
Appearance White to off-white solid
CAS # 789-61-7
Molecular Formula C₁₀H₁₃N₅O₃S
Molecular Weight 283.31
Purity ≥97% by HPLC
Solubility DMSO:H₂O (1:2) (50 mM)
SMILES C1C(C(OC1N2C=NC3=C2NC(=NC3=S)N)CO)O
InChi InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
InChi Key SCVJRXQHFJXZFZ-KVQBGUIXSA-N
PubChem CID 3000603
MDL Number MFCD00672275
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

6-Thio-dG induces telomere dysfunction in telomerase-positive human cancer cells and hTERT-expressing human fubroblasts, but not in telomerase-negative cells. Treatment with 6-thio-dG results in rapid cell death for a wide variety of cancer cells, whereas normal human fibroblasts and human colonic epithelial cells are mostly unaffected.


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