Product Details
| Alternate Name | 2,4-Lutidinic acid, 2,4-Dicarboxypyridine, 4-carboxypicolinic acid, histone lysine demethylase inhibitor, Lutidinic acid |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 499-80-9 |
| Molecular Formula | C₇H₅NO₄ |
| Molecular Weight | 167.12 |
| Purity | ≥98% |
| Solubility | ~1.4 mg/ml in DMSO |
| SMILES | C1=CN=C(C=C1C(=O)O)C(=O)O |
| InChi | InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12) |
| InChi Key | MJIVRKPEXXHNJT-UHFFFAOYSA-N |
| PubChem CID | 10365 |
| MDL Number | MFCD00006296 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
2,4-Pyridinedicarboxylic Acid is an inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases. It structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus inhibiting a range of enzymes. As a 2-OG mimic it also inhibits prolyl, collagen and lysyl hydroxylases. It modulates hypoxia-inducible factor turnover, collagen synthesis and plant cell wall formation. It also inhibits zinc-dependent enzymes, like metallo-β-lactamase. It inhibits several Jumonji domain-containing lysine demethylases such as JMJD2A (KDM4A) and KDM4C. It reduced neointimal hyperplasia and inflammation in the carotid arteries of Diabetic Rats.
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