2,4-Pyridinedicarboxylic Acid

An inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases
Catalog #: B2809 | abID:

Product Details

Alternate Name 2,4-Lutidinic acid, 2,4-Dicarboxypyridine, 4-carboxypicolinic acid, histone lysine demethylase inhibitor, Lutidinic acid
Appearance Crystalline solid
CAS # 499-80-9
Molecular Formula C₇H₅NO₄
Molecular Weight 167.12
Purity ≥98%
Solubility ~1.4 mg/ml in DMSO
InChi InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
PubChem CID 10365
MDL Number MFCD00006296
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


2,4-Pyridinedicarboxylic Acid is an inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases. It structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus inhibiting a range of enzymes. As a 2-OG mimic it also inhibits prolyl, collagen and lysyl hydroxylases. It modulates hypoxia-inducible factor turnover, collagen synthesis and plant cell wall formation. It also inhibits zinc-dependent enzymes, like metallo-β-lactamase. It inhibits several Jumonji domain-containing lysine demethylases such as JMJD2A (KDM4A) and KDM4C. It reduced neointimal hyperplasia and inflammation in the carotid arteries of Diabetic Rats.

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