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2',3',5'-triacetyl-5-Azacytidine

A prodrug and inhibitor of DNA methyl transferase
Catalog #: B2822
SKU-Size Size Price Qty
B2822-5 5 mg
$95.00
B2822-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)oxolan-2-yl]methyl acetate, (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
Appearance Crystalline solid
CAS # 10302-78-0
Molecular Formula C₁₄H₁₈N₄O₈
Molecular Weight 370.31
Purity ≥95%
Solubility ~30 mg/ml in ethanol, DMSO and DMF
~10 mg/ml in PBS, pH 7.2
SMILES CC(=O)OCC1C(C(C(O1)N2C=NC(=NC2=O)N)OC(=O)C)OC(=O)C
InChi InChI=1S/C14H18N4O8/c1-6(19)23-4-9-10(24-7(2)20)11(25-8(3)21)12(26-9)18-5-16-13(15)17-14(18)22/h5,9-12H,4H2,1-3H3,(H2,15,17,22)/t9-,10-,11-,12-/m1/s1
InChi Key OTQJVHISAFFLMA-DDHJBXDOSA-N
PubChem CID 24864108
MDL Number MFCD11113159
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

2',3',5'-triacetyl-5-Azacytidine is an oral prodrug form of 5-Azacytidine. 5-Azacytidine is an inhibitor of DNA methyltransferase, which can reverse epigenetically silenced genes. 2',3',5'-triacetyl-5-Azacytidine inhibits methylation and improves life expectancies in murine L1210 lymphocytic leukemia models.


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