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17β-Hydroxywortmannin

A potent phosphoinositide 3-kinase (PI3K) inhibitor
Catalog #: B2095

In stock

SKU-Size Size Price Qty
B2095-1 1 mg
$85.00
B2095-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 17β-hydroxy-11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
Appearance Off-white solid
CAS # 58053-83-1
Molecular Formula C₂₃H₂₆O₈
Molecular Weight 430.5
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES CC(=O)OC1CC2(C(CCC2O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
InChi InChI=1S/C23H26O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-15,25H,5-7,9H2,1-4H3/t12-,13+,14-,15+,22-,23-/m0/s1
InChi Key XLJORQYAOTYVQS-OGCOKEDGSA-N
PubChem CID 9867340
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

17β-Hydroxywortmannin is an analog of wortmannin (Cat. No. 1670) that irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC₅₀ = 5 nM). 17β-Hydroxywortmannin inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC₅₀ = 1.46 μM)


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