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17-DMAG hydrochloride

A Hsp90 inhibitor
Catalog #: 1776
SKU-Size Size Price Qty
1776-1 1 mg
1776-5 5 mg
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Product Details

Alternate Name 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride; Alvespimycin
Appearance Purple solid
CAS # 467214-21-7
Molecular Formula C₃₂H₄₈N₄O₈•HCl
Molecular Weight 653.21
Purity ≥98% by HPLC
Solubility DMSO or H₂O ( 2 mg/ml)
InChi InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
PubChem CID 9852573
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A water-soluble analog of 17-AAG (Cat. No. 1774-1,5) that displays better stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Binds specifically to heat shock protein90 (Hsp90) in a manner similar to geldanamycin.

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