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A Hsp90 inhibitor
Catalog #: 1774
SKU-Size Size Price Qty
1774-1 1 mg
1774-5 5 mg
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Product Details

Alternate Name 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; Tanespimycin; NSC330507
Appearance Purple solid
CAS # 75747-14-7
Molecular Formula C₃₁H₄₃N₃O₈
Molecular Weight 585.69
Purity ≥98% by HPLC
Solubility DMSO (150 mg/ml) or EtOH (5 mg/ml)
InChi InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
PubChem CID 6505803
MDL Number MFCD04973892
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2 µM) in a manner similar to geldanamycin. Exhibits 100-fold higher affinity for tumor-derived Hsp90 over normal cells. Also inhibits Akt activation and HER2 expression in tumor cells.

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