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1400W dihydrochloride

A highly selective iNOS inhibitor
Catalog #: 2055
SKU-Size Size Price Qty
2055-5 5 mg
2055-25 25 mg
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Product Details

Alternate Name N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl
Appearance White to off-white solid
CAS # 214358-33-5
Molecular Formula C₁₀H₁₅N₃ . 2HCl
Molecular Weight 250.17
Purity ≥98% by NMR
Solubility Water (100 mM)
InChi InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
PubChem CID 2733515
MDL Number MFCD03428622
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Kᵢ values of 2 and 50 µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.

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