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Product Details
| Alternate Name | 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone |
|---|---|
| Appearance | Yellow solid |
| CAS # | 403811-55-2 |
| Molecular Formula | C₁₂H₁₁NOS₂ |
| Molecular Weight | 249.35 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (60 mg/ml) or EtOH (20 mg/ml) |
| SMILES | CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2 |
| InChi | InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+ |
| InChi Key | SVXDHPADAXBMFB-JXMROGBWSA-N |
| PubChem CID | 1271002 |
| MDL Number | MFCD00758517 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
10058-F4 is a c-Myc inhibitor that inhibits the c-Myc-Max associationn and function. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia. 10058-F4 inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells.
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