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10-Hydroxycamptothecin

A potent topoisomerase I inhibitor
Catalog #: B1995

In stock

SKU-Size Size Price Qty
B1995-25 25 mg
$85.00
B1995-100 100 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name 4-(1-(1,3-Benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl)-butan-oic acid; IVA-337
Appearance White solid
CAS # 19685-09-7
Molecular Formula C₂₀H₁₆N₂O₅
Molecular Weight 364.35
Purity ≥95% by HPLC
Solubility DMSO (~3 mg/ml)
SMILES CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChi InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChi Key HAWSQZCWOQZXHI-FQEVSTJZSA-N
PubChem CID 97226
MDL Number MFCD00189425
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

10-Hydroxycamptothecin is a potent topoisomerase I inhibitor. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound (Cat. No. 1039). 10-Hydroxycamptothecin displays strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM).


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