Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

1-NM-PP1

1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases
Catalog #: B2346

In stock

SKU-Size Size Price Qty
B2346-1 1 mg
$85.00
B2346-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine,PP1 analog II
Appearance White solid
CAS # 221244-14-0
Molecular Formula C₂₀H₂₁N₅
Molecular Weight 331.41
Purity ≥98% by HPLC
Solubility >25 mg/ml (DMSO)
SMILES CC(C)(C)N1C2=C(C(=N1)CC3=CC=CC4=CC=CC=C43)C(=NC=N2)N
InChi InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)
InChi Key GDQXJQSQYMMKRA-UHFFFAOYSA-N
PubChem CID 5154691
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Inhibits multiple tyrosine kinase targets, such as v-Src (IC50 = 1 μM), c-Fyn (IC50 = 0.6 μM), c-Abl (IC50 = 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50 = 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values ~ 3 nM).


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.