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1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases
Catalog #: B2346
SKU-Size Size Price Qty
B2346-1 1 mg
B2346-5 5 mg
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Product Details

Alternate Name 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine,PP1 analog II
Appearance White solid
CAS # 221244-14-0
Molecular Formula C₂₀H₂₁N₅
Molecular Weight 331.41
Purity ≥98% by HPLC
Solubility >25 mg/ml (DMSO)
InChi InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)
PubChem CID 5154691
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Inhibits multiple tyrosine kinase targets, such as v-Src (IC50 = 1 μM), c-Fyn (IC50 = 0.6 μM), c-Abl (IC50 = 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50 = 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values ~ 3 nM).

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