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1,5-Isoquinolinediol

A poly(ADP-ribose) synthetase (PARP1) inhibitor
Catalog #: 2415
SKU-Size Size Price Qty
2415-10 10 mg
$65.00
2415-50 50 mg
$175.00
More Sizes Get Quote

Product Details

Alternate Name 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ; NSC 65585
Appearance Off-white solid
CAS # 5154-02-9
Molecular Formula C₉H₇NO₂
Molecular Weight 161.16
Purity ≥98% by TLC
Solubility DMSO (>35 mg/ml)
SMILES C1=CC2=C(C=CNC2=O)C(=C1)O
InChi InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChi Key LFUJIPVWTMGYDG-UHFFFAOYSA-N
PubChem CID 1340
MDL Number MFCD00006900
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. Also acts as a neuroprotective agent.


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