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1,4-DPCA

A competitive inhibitor of prolyl 4-hydroxylase
Catalog #: B3123
SKU-Size Size Price Qty
B3123-5 5 mg
$110.00
B3123-25 25 mg
$435.00
More Sizes Get Quote

Product Details

Alternate Name 4-oxo-1H-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid; 3-Acetyl-1H-[1,10]phenanthrolin-4-one; 4-Hydroxy-1,10-phenanthroline-3-carboxylic acid
Appearance Light brown powder
CAS # 331830-20-7, 53946-49-9
Molecular Formula C₁₃H₈N₂O₃
Molecular Weight 240.21
Purity ≥ 98%
Solubility ~3 mg/ml in DMSO or DMF
SMILES C1=CC2=C(C3=C(C=C2)C(=O)C(=CN3)C(=O)O)N=C1
InChi InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18)
InChi Key XZZHOJONZJQARN-UHFFFAOYSA-N
PubChem CID 459803
MDL Number MFCD07357380
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4 µM, respectively. It also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM. Inhibitors of prolyl 4-hydroxylase maybe useful in controlling excess collagen deposition in pathological fibrosis.


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