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Product Details
| Alternate Name | 4-oxo-1H-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid; 3-Acetyl-1H-[1,10]phenanthrolin-4-one; 4-Hydroxy-1,10-phenanthroline-3-carboxylic acid |
|---|---|
| Appearance | Light brown powder |
| CAS # | 331830-20-7, 53946-49-9 |
| Molecular Formula | C₁₃H₈N₂O₃ |
| Molecular Weight | 240.21 |
| Purity | ≥ 98% |
| Solubility | ~3 mg/ml in DMSO or DMF |
| SMILES | C1=CC2=C(C3=C(C=C2)C(=O)C(=CN3)C(=O)O)N=C1 |
| InChi | InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18) |
| InChi Key | XZZHOJONZJQARN-UHFFFAOYSA-N |
| PubChem CID | 459803 |
| MDL Number | MFCD07357380 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4 µM, respectively. It also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM. Inhibitors of prolyl 4-hydroxylase maybe useful in controlling excess collagen deposition in pathological fibrosis.
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