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Zanamivir

A potent and selective inhibitor of influenza A and B virus neuraminidases
Catalog #: B1900

Availability: In stock

SKU-Size Size Price Qty
B1900-10 10 mg
$85.00
B1900-50 50 mg
$335.00

Product Details

Alternate Name (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
Appearance White solid
CAS # 139110-80-8
Molecular Formula C₁₂H₂₀N₄O₇
Molecular Weight 332.31
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
InChi InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
InChi Key ARAIBEBZBOPLMB-UFGQHTETSA-N
PubChem CID 60855
MDL Number MFCD00866966
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Zanamivir is a potent and selective inhibitor of influenza A and B virus neuraminidases with IC₅₀ values of 0.95 nM and 2.7 nM, respectively. It interacts with a group of amino acids in the active site of neuraminidase, that are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which blocks the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions.


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